human ipsc derived dopaminergic neurons

The depleted dopamine levels, dopaminergic neurons loss, and intraneuronal cytoplasmic inclusions termed as Lewy Bodies (LB) in surviving substantia nigra pars compacta (SNpc) neurons are the pathological hallmarks of PD. The SNpc contains the soma of nigrostriatal neurons and projects them to the putamen. The pattern of SNpc cell loss appears parallel to the expression levels of the dopamine transporter (DAT) transcript and is consistent with the finding that dopamine loss is most pronounced in the dorsolateral putamen, the main site of projection for these neurons.