The two powerhouses of the NRL will do battle at Bankwest Stadium in a match that will have a major bearing on the top four race.
The Eels are coming off a hard-fought win over the Warriors last week, while the Rabbitohs suffered a shock loss to the Titans.
There is no love lost between these two sides, and the atmosphere is sure to be electric.
The Eels will be looking to Mitchell Moses to lead them around the park, while the Rabbitohs will be hoping for a big performance from Cody Walker.
Both teams have a number of key players in doubt, but the Eels are expected to be at full strength.
The Rabbitohs will be without the suspended Latrell Mitchell, while the Eels will be missing Ryan Matterson.
It's shaping up to be a fascinating contest, and one that is sure to have plenty of twists and turns.
Here are some of the key matchups to watch out for:
Prediction:
The Eels are the form team at the moment, and they will be confident of beating the Rabbitohs at home.
However, the Rabbitohs are a dangerous team, and they will be looking to bounce back from their loss last week.
This is a tough match to call, but I'm going to give the Eels the edge.
Eels by 6.
What do you think? Let me know in the comments below.