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Keywords Refractory epilepsy В· Drug resistant epilepsy В· Antiepileptic drugs В· Medication lay out В· Transporter premise В· Objective theory В· Intrinsic grimness proposition В· ABC transporters В· Multi-target directed drugs В· Nanocarriers 14. The three Rs tabulate Replacement, which commonly refers to the use of in vitro or computer models to conduct research in place of of animals; Reduction, which refers a wane in the number of animals acquainted with by reducing the variables through good experiential conceive; and Minutia, which refers to a switch in the study design that leads to a reduction or replacement of animals and minimizes or eliminates suffering or dis- tress. Cranky, peckish
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