LDD Characterization

There are many strategies to overcome this problem by increasing solubility and improving delivery efficiency, and one of the promising techniques is lipid-based drug delivery (LDD). In particular, nanotechnologies are incresingly used in the field of lipid-based drug delivery, with the aim of improving the stability and pharmacokinetics (PK) of hydrophobic drugs by increasing their cell uptake and targeting of specific tissues. For example, solid lipid nanoparticles used for drug delivery can self-assemble into stable, safe and biodegradable nanoparticles (NPs), in which the core provides a reservoir for hydrophobic drugs. Lipids can also promote oral absorption and transport of encapsulated drugs, as well as enhance the oral bioavailability of hydrophobic drugs, and are therefore considered to be very attractive drug delivery vehicles.