Two of the NRL's most passionate rivals will go head-to-head at Accor Stadium on Thursday in what is expected to be a high-quality contest.
Currently sitting third on the NRL ladder, the Panthers are in great form and will be looking to make a statement against their bitter rivals.
The Rabbitohs, meanwhile, are currently in seventh position but will be confident of causing an upset after their impressive performance against the Roosters last week.
The match is likely to be decided by the battle of the forwards.
The Panthers' packThe Panthers have one of the most formidable forward packs in the NRL, led by captain James Tamou.
Tamou is a powerful prop who is always a handful for opposition teams.
Other key forwards in the Panthers' pack include Liam Martin, Scott Sorensen and Spencer Leniu.
These players are all great ball-carriers and tacklers, and they will be looking to lay the platform for victory against the Rabbitohs.
The Rabbitohs' packThe Rabbitohs have a strong forward pack of their own, led by captain Cameron Murray.
Murray is a tireless worker who is always putting in a big shift.
Other key forwards in the Rabbitohs' pack include Tom Burgess, Tevita Tatola and Patrick Carrigan.
These players are all dangerous runners and they will be looking to get the Rabbitohs on the front foot against the Panthers.
The battle of the halvesThe battle between Nathan Cleary and Cody Walker will be another key aspect of the game.
Cleary is one of the best young players in the NRL and he is always a threat with the ball in hand.
Walker is also a very talented player and he will be looking to lead the Rabbitohs to victory.
The key match-ups
These are just a few of the key match-ups that could decide the outcome of the game.
The match is sure to be a close one and it could go either way.
The Panthers will be looking to make a statement against their rivals, while the Rabbitohs will be confident of causing an upset.
Who will win?
The Panthers are the favorites going into the match, but the Rabbitohs are a dangerous team and they will be confident of causing an upset.
Ultimately, the match will come down to who can execute their game plan better on the day.
The Panthers have the slightly better team on paper, but the Rabbitohs have a lot of experience in big games.
It's going to be a close one, but I'm going to give the Panthers the slight edge.