The two clubs have met 119 times since their first clash in 1908, with the Rabbitohs holding a narrow 61-54 advantage. The Tigers have won the past two meetings, however, and will be looking to make it three in a row when they host the Rabbitohs at Leichhardt Oval on Saturday night.
The Tigers have been in good form in recent weeks, winning three of their past four games. The Rabbitohs, on the other hand, have been struggling, losing three of their past four games.
The Tigers will be boosted by the return of Luke Brooks, who missed last week's win over the Broncos with a hamstring injury. Brooks is a key player for the Tigers, and his return will give them a major boost.
The Rabbitohs will be without Cody Walker, who is suspended for the match. Walker is a key player for the Rabbitohs, and his absence will be a big blow.
The match is expected to be a close one, and it could go either way. The Tigers will be looking to make it three wins in a row, while the Rabbitohs will be looking to get back on track.
Here are some of the key matchups to watch in the game: